Epigenetics and epigenomcs are main themes featured in this “Nature Biotechnology” issue. DNA methylation, histone modification, nucleosome positioning, how these modifications influence different states of cellular development, which technologies are available and how analysis of such data can be approached. MeDIP, BS, MRE, ChIP – now these technologies are tghtly associated with sequencing. Besides excellent education about epigenetecs these 3-5 page commentaries provide lots of specifics, i.e. references to databases and efforts to unify epigenetics data collection and processing. NIH Roadmap Epigenomics Mapping Consortium (http://www.roadmapepigenomics.org/), Data access @ NCBI epigenomics portal (http://www.ncbi.nlm.nih.gov/geo/roadmap/epigenomics/), Data Analysis and Coordination Center (http://www.epigenomeatlas.org/) – several of many resources. Given that besides methylation we have >100 other genome modifications there’s a lot of exciting work to do! A must, since it is the future of biotechnology.
http://www.nature.com/nbt/journal/v28/n10/index.html
